Two-Component and Regulatory Proteins

P2RP

P2RP (Predicted Prokaryotic Regulatory Proteins) - users can input amino acid or genomic DNA sequences, and predicted proteins therein are scanned for the possession of DNA-binding domains and/or two-component system domains. RPs identified in this manner are categorised into families, unambiguously annotated.
(Reference: Barakat M, et al. 2013. BMC Genomics 14:269).


P2CS

P2CS (Prokaryotic 2-Component Systems) is a comprehensive resource for the analysis of Prokaryotic Two-Component Systems (TCSs). TCSs are comprised of a receptor histidine kinase (HK) and a partner response regulator (RR) and control important prokaryotic behaviors. It can be searched using BLASTP.
(Reference: P. Ortet et al. 2015. Nucl. Acids Res. 43 (D1): D536-D541).

Updated: December, 2025