Specialized Annotation - CRISPR
CRISPRfinder
CRISPRfinder
- enables the easy detection of CRISPRs in locally-produced data and
consultation of CRISPRs present in the database. It also gives
information on the presence of CRISPR-associated (cas) genes when they
have been annotated as such.
(Reference: I. Grissa et al. 2007. Nucl. Acids Res.
35 (Web Server issue): W52-W57).
CRISPRmap
CRISPRmap
-provides a quick and detailed insight into repeat conservation and
diversity of both bacterial and archaeal systems. It comprises the
largest dataset of CRISPRs to date and enables comprehensive independent
clustering analyses to determine conserved sequence families, potential
structure motifs for endoribonucleases, and evolutionary relationships.
(Reference: S.J. Lange et al. 2013. Nucleic Acids
Research, 41: 8034-8044).
CRISPI
CRISPI
: a CRISPR Interactive database - includes a complete repertory of
associated CRISPR-associated genes (CAS). A user-friendly web interface
with many graphical tools and functions allows users to extract results,
find CRISPR in personal sequences or calculate sequence similarity with
spacers.
(Reference: Rousseau C et al. 2009. Bioinformatics.
25: 3317–3318).
CRISPRTarget
CRISPRTarget
- that predicts the most likely targets of CRISPR RNAs. This can be used
to discover targets in newly sequenced genomic or metagenomic data.
(Reference: Biswas A et al. 2013. RNA Biol.
10:817-827).
CRISPy-web
CRISPy-web
- is an easy to use web tool based on CRISPy to design sgRNAs for any
user-provided microbial genome. CRISPy-web allows researchers to
interactively select a region of their genome of interest to scan for
possible sgRNAs. After checks for potential off-target matches, the
resulting sgRNA sequences are displayed graphically and can be exported
to text files.
(Reference: K. Blin et al. 2016. Synthetic and
Systems Biotechnology 1(2): 118-121).
PaCRISPR
PaCRISPR
- Anti-CRISPRs are widespread amongst bacteriophage and certain mobile
genetic elements (such as transposons and prophage) and by inactivating
the bacterial host's CRISPR-Cas defence system, anti-CRISPRs promote
bacteriophage infection and horizontal gene transfer. PaCRISPR accurately
identifies anti-CRISPRs from protein datasets derived from genome and
metagenome sequencing projects
(Reference: Wang J et al. Nucleic Acids Research,
48: W348–W357).
Updated: December, 2025