Correcting Genome Annotations

Correcting Genome Annotations

One of the problems with GenBank is that scientists do not update their submission data nor correct errors. In part this is due to laziness; but is also due to the fact that GenBank is, in most cases, unwilling to accept a new version of the Sequin file. Tbl2asn is a command-line program that automates the creation of sequence records for submission to GenBank but, from my perspective, it is not easy to use. The only online program is GenBank 2 Sequin which generates not only a Sequin file (*.sqn), but also a five-column "Annotation Table" (*.tbl). This together with the fasta-formatted DNA sequence can be submitted to GenBank by Email (gb-admin@ncbi.nlm.nih.gov). In its absence I recommend the perl script gbf2tbl.pl available for downloading here.